Demineralized bone matrix a bone which has undergone allotransplantation. Theinorganic mineral is removed from the bone leaving the organic collagen matrix. Removing the bone mineral leads to the exposal of bone morphogenetic proteins which are biologically more active. These factors of growth are responsible for the modulation of progenitor cells differentiation resulting in osteoprogenitor cells which form cartilage and bone. Demineralized bone matrix becomes biologically active as compared to the bone grafts which are undemineralized as a result of the demineralization procedure. This procedure significantly leads to the reduction of the mechanical properties of the demineralized bone matrix.
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Market trends for demineralized bone matrix
The global market for demineralized bone matrix is estimated to increase at significant compound annual growth rate (CAGR) during the forecast period of 2014-2022. The ability of this technique to stimulate the bone formation has been the market driving factor for this. Growth in the geriatric population and positive aspects of the technique such as faster recovery, reduced postoperative time has led to the expansion of the market industry for demineralized bone matrix.
Further details about demineralized bone matrix
The concept of demineralized bone matrix has become popular in the recent times. The ability of a grafted bone to set up the host cells on the grafted area and carry outthe modulation of their conversion to the cells which are responsible for the formation of bone which include osteoblasts in order to restore the defect is used to determine whether a bone graft is successful or not. This in turn depends on the osteoinductive, osteoconductive and osteogenic abilities possessed by the graft. The autograft bone collected from iliac crest is taken to be the gold standard at present. The application of this is bound due to the conditions such as limited availability of bone which would play the role of donor for this procedure, increased surgery duration, morbidity of the donor site and increased recovery time. Autograft has allograft bone as its logical alternative option but this carries negative aspects with itself. It has to be sterilized edgily and processed rigorously before implanting it in order to eradicate the risk of any immunological response and chances of transmission of the disease. The processing of the bone sweeps off the osteoinductive and osteogenic capabilities of the graft, thus leaving just an osteoconductive scaffold behind. The residual scaffolds are present in a number of preparations which include struts and morselized particles in case of various orthopaedic applications.
Demineralized bone matrix has emerged as an useful technique in the medical field. The corresponding results have come up to meet the expectations, hence adding up to the growth in its market.