Dry powder inhalers (DPIs) are powdered medicines sealed in containers and are breath-activated, i.e., the powdered medicine is sucked out while inhaling out of the mouthpiece of the device. This method is more effective than the other kind wherein the canister is pushed down in order to release the medicine with pressurized metered-dose inhalers (pMDIs) or commonly called, ‘puffers’. Dry powder inhaler device helps in rendering medication directly to the lungs, and are widely used to treat respiratory diseases such as bronchitis, asthma, COPD, and emphysema. Also, many a time, DPIs such as inhalable insulin Afrezza have also been prescribed by healthcare professionals for the treatment of diabetes mellitus. The two key types of the most common DPI which comprises of multiple doses of medicines are accuhaler and turbuhaler. Prior to inhaling the powder from the mouthpiece, one must load a said dosage by sliding grip with a thumb along a disc-shaped device, i.e., accuhaler, or by twisting the bottom grip on a tube-like device, i.e., turbuhaler. A few of the powdered medicines are available as other types of DPI, which includes handihaler, breezhaler, aerolizer, spinhaler, and rotahaler devices. All of these devices come with capsules filled with the powdered medicine which should be loaded into the chamber within the device. The inhaled drug delivery systems are separated into three primary categories, such as pressurized metered-dose inhalers (pMDIs), DPIs, and nebulizers, and each of this class with its exclusive strengths and weaknesses. In a recent analysis done on the dry powder inhaler device market, it suggested that only 14% of over 1500 physicians surveyed have enough knowledge of inhaled therapy and out of these, less than 50 percent actually knew thoroughly the right inhalation maneuvering needed from a DPI device.
Advantages of Dry Powder Inhaler:
Minimum to no patient coordination needed
Propellant-free design and environmental sustainability
Disadvantages of Dry Powder Inhaler:
Possibility for dosage uniformity issues
Manufacturing can be complex and not very cost-efficient
Deposition efficacy dependant on patient’s inspiratory flow.
How to use the Dry Powder Inhaler:
The use of DPI in a right manner is of utmost importance and this assists that the appropriate amount of medicine is rendered to the lungs and also will help in minimizing the side effects. One must keep his/her head upright while using the inhaler and also always rinse the mouth with water, gargle and spit immediately post using any inhaler which has an inhaled corticosteroid to lessen the possibilities of side effects.